In the opener, West Chester scored twice in the first, once in the second, and three more times in the third to jump out to a 6-0 lead.
USciences battled back with a pair in the third, but could only muster one more run in their final at-bats in the seventh.
Mike Ferrara hit his second home run of the season as the Golden Rams scored six runs on just four hits.
Keith Flaherty went 5-for-5 with two home runs and six RBI in game two, and right-hander Joe Sperone tossed a complete-game, seven-inning, shutout on the mound as West Chester (6-0) ran its season-opening winning streak to six straight.
In other D-II action
Southern Connecticut knocked off Chestnut Hill on Sunday, 12-10.
Sam Barletta, Andrew Dietz, and Nick Delacruz collected two hits each in the loss. Barletta also walked four times. The loss knocked the Griffins to 1-3 on the season.
